Tetrahydroxystilbene Glucoside Suppresses NAPDH Oxidative Stress to Mitigate Apoptosis and Autophagy Induced by Cerebral Ischemia/Reperfusion Injury in Mice

Figure 2

TSG decreased the oxygen free radical, MDA, and NOX4 production, but increased SOD level in ischemic penumbra of I/R mice. (a) Oxygen free radical levels in brain tissues of each group; (b) SOD levels in the brain tissues of each group; (c) MDA levels in brain tissues of each group. (d) Typical NOX4 protein expression graph in brain tissue cortex in each group. (e) Semiquantitative analysis results of NOX4 protein expression in brain tissue cortex. (f) Typical NOX4 protein expression graph in brain tissue hippocampus in each group. (g) Semiquantitative analysis results of NOX4 protein expression in brain tissue hippocampus. Data are mean±SEM (n=5). ^##p<0.01 compared with sham group. ∗∗p<0.01 compared with I/R group.

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