Prophylactic Repetitive Treatment with the Herbal Medicine Kei-kyoh-zoh-soh-oh-shin-bu-toh Attenuates Oxaliplatin-Induced Mechanical Allodynia by Decreasing Spinal Astrocytes
Figure 3
Effect of prophylactic repetitive oral administration of Kei-kyoh-zoh-soh-oh-shin-bu-toh (KSOT) on the mechanical allodynia induced by chemotherapeutic agents. Mice were given a single injection of (a) oxaliplatin (OXP, 3 mg/kg, i.p.), (b) paclitaxel (PTX, 5 mg/kg, i.p.), (c) vincristine (VCN, 0.1 mg/kg, i.p.), (d) bortezomib (BTZ, 0.3 mg/kg, i.v.) or the corresponding vehicles (VH1) on day 0. KSOT or the vehicle (VH2) orally administered once daily from the day after a single injection of chemotherapeutic agent or the corresponding vehicle (VH1). Mechanical allodynia was evaluated using a fine von Frey filament (0.69 mN strength). Data are presented as mean ± standard errors of the mean (n = 6). P < 0.05 vs. OXP + VH2 (Holm-Šidák multiple comparisons). i.p.: intraperitoneal injection, i.v.: intravenous injection.