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| Study ID | Age | Sample size | Experimental | Control group | Observation | Outcomes | Risk of bias |
| (year) | (Experimental/Control) | group measures | measures | time | (Low/Unclear/High) |
|
| Cai 1998 [23] | 1-18 | 57/43 | The experimental group used Xijiao Dihuang Decoction, clinical routine dose, 2 times a day | The control group received Basic western medicine treatment | 6 months | (1)(3) | Low |
|
| Chen 2014 [24] | 3-12 | 40/40 | Xijiao Dihuang Decoction, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(4) | Unclear |
|
| Cui 2011 [25] | 4-13 | 126/120 | The experimental group used Xijiao Dihuang Decoction, clinical routine dose, 2 times a day | The control group received Basic western medicine treatment | 6 months | (2) | Unclear |
|
| Han 2006 [26] | 6-14 | 30/25 | Xijiao Dihuang Decoction, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | High |
|
| Lu 2003 [5] | 4-14 | 38/30 | Xijiao Dihuang Decoction, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | High |
|
| Sun 2016 [27] | 3-14 | 40/40 | The experimental group used Xijiao Dihuang Decoction, clinical routine dose, 2 times a day | The control group received Basic western medicine treatment | 2 weeks | (1) | Unclear |
|
| Wu 2014 [12] | 3-16 | 58/52 | Xijiao Dihuang Decoction, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | Low |
|
| Yan 2014 [28] | 3-12 | 40/40 | Xijiao Dihuang Decoction, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(4) | Low |
|
| Yang 2012 [29] | 3-16 | 43/40 | The experimental group used Xijiao Dihuang Decoction, clinical routine dose, 2 times a day | The control group received Basic western medicine treatment | 3 weeks | (1)(3) | Low |
|
| Zhan 2015 [30] | 1-18 | 22/23 | The experimental group used Xijiao Dihuang Decoction, clinical routine dose, 2 times a day | The control group received Basic western medicine treatment | 6 weeks | (1) | Unclear |
| Zhao 2017 [31] | 2-14 | 81/27 | Xijiao Dihuang Decoction, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(4) | Low |
|
| Wang 2016 [6] | 5-14 | 50/50 | Modified Huaban Decoction, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating spots and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 1 year | (1) | Unclear |
|
| Chen 2015 [7] | 3-10 | 30/30 | Wuteng Granules, clinical routine dose, 2 times a day. This Granule consists of Chinese herbs for cooling blood and eliminating wind and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 8 weeks | (1)(2)(3)(4) | Low |
|
| Chen 2012 [32] | 4-11 | 29/28 | Xijiao Dihuang Decoction, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 3 weeks | (1)(2)(4) | Unclear |
|
| Ma 2018 [13] | 5-18 | 30/30 | Kunxian Granules, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 months | (1) | Unclear |
|
| Lv 2017 [8] | 6-15 | 30/30 | Liangxue Xiaodian Decoction, clinical routine dose, 2 times a day. The composition of this Formula is based on the addition and subtraction of Xijiao Dihuang Decoction. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 4 weeks | (1)(3) | Unclear |
|
| Gui 2017 [33] | 3-14 | 100/100 | Huaiqihuang Granules, clinical routine dose, 2 times a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 3 months | (1)(2)(3) | Low |
|
| Shen 2013 [14] | 4-15 | 60/60 | Shitan Decoction, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and clearing away heat and detoxification. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | Unclear |
|
| Wang 2017 [34] | 3-17 | 40/40 | Self-Designed Formula, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating spots and clearing away heat and detoxification. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(3) | Low |
|
| Hou 2008 [35] | 12-18 | 30/30 | Xiaofeng Formula, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating wind and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | Unclear |
|
| Gong 2017 [15] | 3-16 | 60/60 | Zidian Zhenxiao Granules, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and clearing away heat and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | Unclear |
|
| Song 2015 [16] | 5-13 | 30/30 | Yinqiao Formula, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and clearing away heat. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 6 months | (1)(3) | Low |
|
| Huang 2013 [36] | 1-12 | 51/51 | Self-Designed Formula, clinical routine dose, 2 times a day. The composition of this Formula is based on the addition and subtraction of Xijiao Dihuang Decoction. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 6 months | (1)(3) | Low |
|
| Kang 2014 [17] | 2-13 | 23/22 | Choose the appropriate treatment according to different syndrome types. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 3 weeks | (1) | Low |
|
| Wang 2015 [9] | 5-17 | 69/69 | Self-Designed Formula, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating wind and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(3) | Unclear |
|
| Cheng 2010 [18] | 6-14 | 18/17 | Choose the appropriate treatment according to different syndrome types. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(2)(4) | High |
|
| Chen 2016 [37] | 3-14 | 81/81 | Self-Designed Formula, clinical routine dose, 2 times a day. The composition of this Formula is based on the addition and subtraction of Xijiao Dihuang Decoction. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(3)(4) | Low |
|
| Sun 2017 [38] | 3-12 | 32/32 | Salvia Injection, 10mL a day. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | High |
|
| Zhu 2016 [19] | 0.5-6 | 30/30 | Self-Designed Formula, clinical routine dose, 2 times a day. The composition of this Formula is based on the addition and subtraction of Xijiao Dihuang Decoction. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | Unclear |
|
| Liu 2012 [20] | 3-14 | 36/32 | Choose the appropriate treatment according to different syndrome types. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 4 weeks | (1)(3) | Low |
|
| Xie 2017 [39] | 1-12 | 46/46 | Modified Huaban Decoction, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating spots and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 4 weeks | (1)(3) | Low |
|
| Zhou 2015 [40] | 4-16 | 40/40 | Choose the appropriate treatment according to different syndrome types. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | High |
|
| Min 2014 [41] | 1-17 | 61/52 | Self-Designed Formula, clinical routine dose, 2 times a day. The composition of this Formula is based on the addition and subtraction of Xijiao Dihuang Decoction. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 3 weeks | (1) | Low |
|
| Huang 2015 [42] | 2-8 | 40/40 | Choose the appropriate treatment according to different syndrome types. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | High |
|
| Wang 2011 [43] | 2-13 | 45/33 | Kangmin Xiaodian Decoction, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating wind and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 3 weeks | (1) | Unclear |
|
| Wen 2016 [21] | 3-14 | 30/30 | Liangxue Xiaoban Decoction, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating spots. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1) | Unclear |
|
| Jiang 2014 [44] | 4-11 | 30/30 | Self-Designed Formula, clinical routine dose, 2 times a day. This Formula consists of Chinese herbs for cooling blood and eliminating spots and clearing away heat. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 2 weeks | (1)(3) | Low |
|
| Zhou 2005 [10] | 2-14 | 54/28 | Choose the appropriate treatment according to different syndrome types | The control group received Basic western medicine treatment | 2 weeks | (1) | Unclear |
|
| Zhang 2016 [45] | 6-16 | 128/128 | Zidan Particles, clinical routine dose, 2 times a day. This Particles consists of Chinese herbs for cooling blood and clearing away heat and removing extravasated blood and dredge Collaterals. The basic treatment is same as the control group | The control group received Basic western medicine treatment | 4 weeks | (1)(2) | Low |
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