Efficacy and Safety of Chinese Herbs for the Prevention of the Risk of Renal Damage in Henoch-Schonlein Purpura in Children: Meta-Analysis of Randomized Controlled Trials and GRADE Evaluation

Table 2

Evaluation of GRADE in children with HSP treated by Chinese herbs.

Chinese herbs compared to Basic treatment for HSP
Patient or population: patients with HSP
Settings: RCT
Intervention: Chinese herbs
Outcomes	Illustrative comparative risks		Relative effect; (95% CI)	No of Participants  (studies)	Quality of the evidence  (GRADE)	Comments
	(95% CI)
	Assumed risk	Corresponding risk
	Basic treatment	Chinese herbs
efficient	Study population		OR 4.31; (3.34 to 5.57)	3137; (36 studies)	⊕⊕⊕  ⊝; moderate^1
	811 per 1000	949 per 100
		(935 to 960)
	Moderate
	808 per 1000	948 per 1000
		(934 to 959)
renal injury rate	Study population		RR 0.36; (0.21 to 0.61)	654; (5 studies)	⊕⊕⊕  ⊝; moderate^1
	139 per 1000	50 per 1000
		(29 to 85)
	Moderate
	148 per 1000	53 per 1000
		(31 to 90)
recurrence rate	Study population		RR 0.43; (0.34 to 0.54)	1060; (12 studies)	⊕⊕⊕  ⊝; moderate^1
	320 per 1000	138 per 1000
		(109 to 173)
	Moderate
	276 per 1000	119 per 1000
		(94 to 149)

basis for the assumed risk (e.g., the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; RR: risk ratio; OR: odds ratio.
GRADE Working Group grades of evidence.
High quality: further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: we are very uncertain about the estimate.
¹ Random, blinded risk of bias.