In a Rat Model of Acute Liver Failure, Icaritin Improved the Therapeutic Effect of Mesenchymal Stem Cells by Activation of the Hepatocyte Growth Factor/c-Met Pathway

<p>ICT+MSCs and MSCs improved liver histopathology and reduced the apoptosis of hepatocytes. (a) Hematoxylin and eosin staining of liver sections (400 ×). (b) qRT-PCR and western blot analysis of (cleaved) caspase 3, Bax, and Bcl-2 at 24h after induction of the ALF model. (c) qRT-PCR and western blot analysis of (cleaved) caspase 3, Bax, and Bcl-2 at 48 h after induction of the ALF model. <sup>∗</sup>P &lt; 0.05<i> vs. </i>NS group; <sup>#</sup>P &lt; 0.05<i> vs. </i>MSCs group. Data are means ± SD. Each experiment was replicated 6 times.</p>

Evidence-Based Complementary and Alternative Medicine

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Figure 2: In a Rat Model of Acute Liver Failure, Icaritin Improved the Therapeutic Effect of Mesenchymal Stem Cells by Activation of the Hepatocyte Growth Factor/c-Met Pathway 

Figure 2 | In a Rat Model of Acute Liver Failure, Icaritin Improved the Therapeutic Effect of Mesenchymal Stem Cells by Activation of the Hepatocyte Growth Factor/c-Met Pathway 