Review Article
Tian Wang Bu Xin Dan for Insomnia: A Systematic Review of Efficacy and Safety
Table 1
Basic characteristics of the included studies.
| | Studies | Sample | Interventions | Duration (weeks) | Outcome
index | Adverse effects | | Trial | Control | Trial | Control | Trial | Control |
| | Zhangwanting 2006 | 36 | 30 | TWBXD | Estazolam | 2 | ① | - | | Limingzi 2012 | 30 | 30 | TWBXD | Bailemian Capsule | 4 | ①②③④ | 0 | 0 | | Chenweiming 2012 | 60 | 30 | TWBXD | Estazolam | 8 | ①②③④ | - | | Guochangxue 2012 | 40 | 40 | TWBXD | Estazolam | 2 | ① | - | | Lipinghua 2013 | 44 | 44 | TWBXD | Estazolam + oryzanol | 4 | ① | - | | Hanyanchao 2013 | 32 | 32 | TWBXD | Alprazolam | 4 | ①② | - | | Zhuzhenhua 2013 | 50 | 50 | TWBXD | Estazolam + oryzanol | 4 | ① | - | | Xiejinping 2014 | 48 | 27 | TWBXD | Diazepam | 4 | ② | - | | Jiangaiju 2015 | 58 | 62 | TWBXD | Estazolam | 4 | ① | - | | Zhangfanguo 2015 | 40 | 40 | TWBXD + Diazepam | Diazepam | 4 | ① | - | | Shichuming 2015 | 50 | 50 | TWBXD + Estazolam | Estazolam | 4 | ① | 0 | 10 | | Liuzhanbing 2015 | 67 | 66 | TWBXD | Alprazolam | 4 | ①② | 2 | 9 | | Wubaojin 2017 | 40 | 40 | TWBXD | Estazolam +oryzanol | 4 | ① | 0 | 1 | | Liushijun 2017 | 60 | 60 | TWBXD | Estazolam | 4 | ①②③④ | 0 | 5 |
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① Clinical effective rate; ② PSQI total score; ③ time required to fall asleep; ④ Quality of sleep.
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