Molecular Changes in Diabetic Wound Healing following Administration of Vitamin D and Ginger Supplements: Biochemical and Molecular Experimental Study
Figure 2
Molecular changes in fibrogenic markers (HPX, collagen, and fibronectin) (a), miRNAs (miR-146a, miR-155, and miR-15a) (b), and percentage of skin wound healing (c) in diabetic and control mice following treatment with gingerols fractions either alone or in combination with vitamin D supplements. There was significant increase in the expression levels of HPX, collagen, and fibronectin in diabetic mice that received gingerols in combination with vitamin D in comparison with diabetic mice only (P=0.001) (a). Also, expression of miRNAs, miR-146a and miR-155, was significantly downregulated in comparison with miR-15a significantly upregulated in diabetic wound tissues following treatment with both gingerols fractions and vitamin D (P=0.001) (b). Maximum wound contraction (90 %-97 %) was reported in diabetic skin wound treated with vitamin D, gingerols fractions, and a combination of both gingerols and vitamin D, respectively (c).