Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis

Figure 1

Histological evaluation of the knee in CIA. Hematoxylin-eosin staining of the knee was performed to investigate joint damage. The sham-control group showed the normal structure (a, e). Joint damage was most serious in the CIA-control group, characterized by severe adhesions and infiltration by inflammatory cells, bone erosion, and cartilage damage (b, e). Inflammatory changes and bone erosion were also detectable in the CIA-EA group, but the joint was damaged to a significantly lesser extent compared with the CIA-control group (b, c, and e). Adhesions and bone damage were worse in the CIA-EA-SCH58261 group compared to the CIA-EA group. The CIA-EA-SCH58261 was similar to the CIA-control group (b, c, d, and e). Data were expressed as mean ± SD and were compared using one-way ANOVA and Tukey HSD multiple comparison post hoc test. indicates P<0.01 versus the sham-control group. △ indicates P<0.01 versus the CIA-control group. # indicates P<0.05 versus the CIA-EA group.

(a) Sham-control

(b) CIA-control

(c) CIA-EA

(d) CIA-EA-SCH58261

(e)