Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis

Figure 2

TNF-α and RANKL concentrations in different treatment groups. TNF-α and RANKL concentrations in serum samples of rats from the CIA-control group were significantly elevated compared to those of the sham-control group. At the same time, we found that EA intervention significantly decreased levels of serum TNF-α and RANKL compared with the CIA-control group. When the antagonist SCH58261 and EA were administered simultaneously, the levels of TNF-α and RANKL increased significantly in comparison to the CIA-EA group. Data were expressed as mean ± SD and were compared using one-way ANOVA and Tukey HSD multiple comparison post hoc test. P<0.05 versus the sham-control group l. △ P<0.05 versus the CIA-control group. # P<0.05 versus the CIA-EA group.

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