Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis

Figure 3

Serum concentrations of PKA, ERK1/2, and NF-κB in different treatment groups. After CIA was established, the concentrations of PKA, ERK1/2, and NF-κB in serum were drastically elevated compared to the sham-control group. EA intervention significantly reduced PKA, ERK1/2, and NF-κB concentrations compared with the CIA-control group. The levels of PKA, ERK1/2, and NF-κB in the CIA-EA-SCH58261 group were higher than those in the CIA-EA group. Data were expressed as mean ± SD and were compared using one-way ANOVA. The PKA data were analyzed by Dunnett’s T3 multiple comparison post hoc test. The data of ERK1/2 and NF-κB were analyzed using Tukey HSD. P<0.01 versus the Sham-control group. △ indicates P<0.05 versus the CIA-control group. # indicates P<0.01 versus the CIA-EA group.

(a)

(b)

(c)