Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis

Figure 5

Quantification of osteoclasts per joint. The number of osteoclasts was low in the sham-control group (a, e). In CIA rats, the number of osteoclasts was drastically elevated compared with the sham-control group (a, b, and e). When EA was administered to CIA rats, the count of osteoclasts was lower in comparison to the CIA-control group (b, c, and e). When EA and A2AR antagonist SCH58261 were administered simultaneously, the number of osteoclasts was significantly increased compared to the CIA-EA group (c, d, and e). Osteoclasts were counted per joint. Data were expressed as mean ± SD and were compared using one-way ANOVA and Dunnett’s T3 multiple comparison post hoc test. indicates P<0.01 versus the sham-control group. △ indicates P<0.01 versus the CIA-control group. # indicates P<0.05 versus the CIA-EA group.

(a) Sham-control

(b) CIA-control

(c) CIA-EA

(d) CIA-EA-SCH58261

(e)