Anti-Inflammatory Effects of Licania macrocarpa Cuatrec Methanol Extract Target Src- and TAK1-Mediated Pathways

Figure 5

In vivo anti-inflammatory effects of Lm-ME. ICR mice were orally injected with 0, 100, or 200 mg/kg Lm-ME or 40 mg/kg of ranitidine 3 times over 2 days. Eight hours after the last oral injection, 300 μl of 150 mM HCl/60% EtOH was orally administrated for 1 h. Stomachs were excised from the mice, and stomach lesions imaged (a). By using Image J software, stomach lesions induced by HCl/EtOH were measured (b). (c) mRNA expression levels of COX-2 from gastritis samples were measured by quantitative real-time PCR. (d) Total and phosphorylated TAK1 levels from gastritis mice were determined by western blotting analysis.

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