Oxidative Stress and TGF-β1/Smads Signaling Are Involved in Rosa roxburghii Fruit Extract Alleviating Renal Fibrosis

Figure 2

Cili alleviates the morphological changes in kidneys after unilateral ureteral obstruction (UUO). Sixty rats were randomized to six groups: sham operation, UUO, UUO with losartan (UUO+losartan), UUO with moderate Cili dose (3 g/kg/d) (UUO+CL moderate), UUO with high Cili dose (6 g/kg/d) (UUO+CL high), and UUO with resveratrol (UUO+Resveratrol). (a) Hematoxylin and eosin (H&E) staining of kidneys was performed. Lesions such as glomerular hypertrophy and vacuolation of renal tubular epithelial cells are indicated by arrows. (b) Masson’s staining of kidneys and quantification of the fibrosis area. Scale bar: 10 μm. N=12/group. The results are expressed as mean ± standard deviation (SD). P<0.01 vs. the sham group; △△P<0.01 vs. the UUO group.

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