Oxidative Stress and TGF-β1/Smads Signaling Are Involved in Rosa roxburghii Fruit Extract Alleviating Renal Fibrosis

Figure 3

Cili attenuates collagen deposition in kidneys after UUO. Sixty rats were randomized to five groups: sham operation, UUO, UUO with losartan (UUO+losartan), UUO with moderate Cili dose (3 g/kg/d) (UUO+CL moderate), and UUO with high Cili dose (6 g/kg/d) (UUO+CL high). Immunohistochemistry for collagen III in kidneys and quantification. Scale bar: 10 μm. N=12/group. The results are expressed as mean ± SD. P<0.01 vs. the sham group; △△P<0.01 vs. the UUO group; ◆◆P<0.01 vs. the losartan group.