Review Article

Chinese Herbal Medicines Compared with N-Acetylcysteine for the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review of Randomized Controlled Trials

Table 1

Characteristics of the included studies.

Study IDSample sizeGender (male/female)AgeCourse of disease/yearSyndrome differentiation of InterventionCourse of treatment/ weeksOutcome
TCTCTCTCTCMTC

Chen HL 201613138/59/460.4 ± 5.959.7 ± 6.32.1 ± 0.62.3 ± 0.4NAYiqi Tongluo Jiedu decoctionNAC12④⑤
Xin DY 2016252415/1014/1065.68 ± 7.5065.88 ± 7.510.94 ± 0.350.93 ± 0.44qi deficiency and blood stasisErjia-xiaozheng decoctionNAC12③⑤
Zhao GJ 2016241815/913/558.84 ± 18.5359.52 ± 19.351.97 ± 1.382.16 ± 1.88deficiency of both qi and yin, phlegm and static blood obstructing lungFuzheng-huaxian decoctionNAC12③④⑤⑥⑦
Zhao GJ 2018303018/1216/1458591.97 ± 1.382.16 ± 1.88deficiency of both qi and yin, phlegm and static blood obstructing lungFuzheng-huaxian decoctionNAC12③④⑤⑦
Fan MR 2012222114/812/960.98 ± 9.2265.12 ± 8.614.21 ± 1.983.73 ± 2.25deficiency of both qi and yin, lung collaterals obstructionFeixiantong decoction+ CMNAC+ CM12③④⑤⑦
Fan CZ 2013202013/711/965 ± 9.4668.1 ± 12.15NANAdeficiency of both qi and yin, lung collaterals obstructionBuxu Tongbi decoction + CMNAC+ CM12③⑤⑦
Li ZH 2015343018/1614/1658.23 ± 8.3559.98 ± 7.432.38 ± 0.452.87 ± 0.12deficiency of both qi and yin, phlegm and static blood obstructing lungYangyin Yifei Tongluo pill+ CMNAC+ CM12④⑤
An SY 2017303014/1613/1766.8 ± 9.361.5 ± 8.73.6 ± 0.93.2 ± 0.8qi deficiency and blood stasisJiawei-xiayuxue decoction + NACNAC24③④⑤
Liu M 20151816NANANANANANAqi deficiency and blood stasisXuefu-zhuyu capsule +NACNAC72①②④⑤⑥⑦
Wang QJ 2016433723/2019/1860.51 ± 6.8259.23 ± 6.9122.32 ± 8.2820.28 ± 6.81yang deficiency
and blood stasis
Wenyang-huayu decoction +NACNAC12
Bao XY 2014303018/1216/1464.90 ± 10.2565.47 ± 12.714.2 ± 1.504.3 ± 1.47deficiency of both qi and yin, phlegm and static blood obstructing lungKangxian granule +NAC+ CMNAC+ CM12④⑦
Yan XX 2015606034/2635/2563.5 ± 1.263.4 ± 1.31.03 ± 0.11.04 ± 0.11qi deficiency and blood stasisBuyang-huanwu decoction +NAC+ CMNAC+ CM24④⑦
Fan MR 2015272817/1118/962.36 ± 10.565.68 ± 10.29NANAdeficiency of pectoral qi, lung collaterals obstructionTongfeiluo- buzongqi decoction +NAC+ CMNAC+ CM12③④⑤⑦

T: treatment group; C: control group; NA: not available; CM: conventional medicine treatment; NAC: N-acetylcysteine; outcome: ① AE-IPF; ② mortality; ③ SGRQ score; ④ lung function; ⑤ 6MWT; ⑥ PaO2; ⑦adverse events.