Evidence-Based Complementary and Alternative Medicine

Research Article

A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis

Table 1

Clusters of RA target PPI network.
ClusterScoreNodesEdgesGene IDs
155551485ADRA2B, APP, POMC, CXCL13, CXCL2, CXCR5, S1PR3, CCR1, S1PR1, LPAR1, C5, C5AR1, CXCR7, CCR3, C3, MTNR1B, CCR6, CCL5, MTNR1A, CCL20, FPR2, PPBP, CCR2, BDKRB2, ANXA1, CCR5, SSTR4, HRH4, CCL21, SST, PDYN, SAA1, CCR10, CCL28, LPAR2, CXCL12, PF4, CCR4, LPAR3, CXCR1, S1PR2, CXCL10, CXCR3, CXCL11, CXCL9, CXCL6, CCR9, CCL25, CXCR4, CXCL16, CXCR6, CNR1, CXCR2, CXCL1, CNR2
227.28354723IGF2, HGF, ALB, TACR2, FIGF, VEGFC, TGFB3, CLU, SERPINF2, GRK5, ADRA1A, A2M, SERPINA1, EDNRA, F2, LTB4R, HTR2A, VWF, VEGFA, TAC1, GHSR, TIMP3, FGB, FN1, TGFB2, GCG, XCL1, TIMP1, GAS6, RARRES2, PIK3R3, PIK3CA, MMRN1, SPARC, F2RL1, EGF, LGALS3BP, ADRBK1, ACTN1, NPSR1, THBS1, TGFB1, F2R, SERPINE1, PLG, GRP, BRS3, TACR3, TACR1, LTB4R2, EDN1, F13A1, EDNRB, IGF1
319.26872684CRHR1, IRF8, IRF1, LTBR, LTB, CGA, LTA, WNT5A, HLA-DRA, PTH, PTHLH, IRF4, CRHR2, ADRB3, ADORA2A, CD4, ADM, IRF3, TNFRSF11A, TNFSF11, PSMD9, HLA-E, PTGER2, CFTR, TF, VCAM1, TNFRSF1B, PTGER4, GBP6, CLTA, CD44, VIPR1, VIP, TNFRSF13C, TNFSF13B, FCGR1A, PSMB5, APOB, PSMD7, IRF5, HLA-DQA2, HLA-DPB1, TNFSF14, HLA-C, HLA-B, B2M, RAMP2, CALCRL, ADRB2, TNF, TRIM21, NCAM1, AGFG1, ARRB1, SYT1, EGFR, CRH, GPR15, LRP2, PSMB9, PSMB8, CIITA, ICAM1, HLA-DRB1, CD40LG, HLA-DRB5, PML, HLA-A, CD3G, HSPA8, LDLR, PSMD12
412.31233197IL2RB, IFI27, PDCD1, IL3, AKT1, PDCD1LG2, CSF2, CSF2RA, IL5, IFI35, PTPN11, ISG20, CSK, BRAF, JAK1, ITGA2B, RAF1, RAP1A, PTPN6, ISG15, EGR1, IL2RA, SOS1, PIK3CD, PIK3CB, IL2RG, INPP5D, LCP2, PEBP1, CD274, IL5RA, MAP2K1, IL2
58.40665269STAT1, KLRC2, EPHB1, UBA1, UBE2L3, COPB1, COPB2, CD59, SOCS3, SRC, CUL1, ZBTB16, CD8A, ARHGEF7, IL6ST, BTK, CCND3, PARK2, INS, E2F1, KLRK1, IL27RA, CD28, FOLR1, DCTN6, DCTN5, STAT5B, NFKBIB, PAK1, PRKCQ, REL, EPHB2, ZNF645, UBA7, CD55, NFKB2, TP53, SOCS1, NFKB1, NFKBIA, CD86, RELB, TYROBP, TMED7, TREM2, KLRD1, EFNB2, E2F2, RNF19A, EFNB1, GORASP1, USO1, PAK3, ITCH, NFKBIE, PRF1, CDK4, COG6, GRAP2, CD80, CD3E, PRKCZ, CDK6, EBI3, IL27