Safety Assessment of Methanol Extract of Melastoma malabathricum L. Leaves following the Subacute and Subchronic Oral Consumptions in Rats and Its Cytotoxic Effect against the HT29 Cancer Cell Line
Table 1
Relative organ weight of Sprague-Dawley rats following the 28-day oral pretreatment with vehicle (Tween 80) or MEMM in the subacute toxicity study.
Organs
Male
Female
Control
Treatment
Control
Treatment
Tween 80
MEMM (mg/kg)
Tween 80
MEMM (mg/kg)
—
500
1000
—
500
1000
Spleen
0.62 ± 0.09
0.53 ± 0.13
0.61 ± 0.17
0.71 ± 0.03
0.63 ± 0.09
0.39 ± 0.03
Heart
0.47 ± 0.04
0.42 ± 0.03
0.46 ± 0.03
0.42 ± 0.05
0.39 ± 0.03
0.42 ± 0.03
Liver
5.35 ± 0.19
5.14 ± 0.44
5.58 ± 0.30
4.97 ± 0.44
5.10 ± 0.27
4.69 ± 0.28
Kidney
1.46 ± 0.06
1.41 ± 0.07
1.55 ± 0.05
1.29 ± 0.12
1.20 ± 0.11
1.08 ± 0.02
Stomach
0.95 ± 0.14
0.78 ± 0.07
0.80 ± 0.06
0.87 ± 0.13
0.71 ± 0.07
0.90 ± 0.04
Lung
0.85 ± 0.04
0.88 ± 0.14
0.99 ± 0.08
0.87 ± 0.04
1.20 ± 0.27
0.77 ± 0.04
Values are expressed as means ± SEM. Groups (n = 6): control (treated with Tween 80); treatments (treated with 500 mg/kg MEMM and 1000 mg/kg MEMM).
