Safety Assessment of Methanol Extract of Melastoma malabathricum L. Leaves following the Subacute and Subchronic Oral Consumptions in Rats and Its Cytotoxic Effect against the HT29 Cancer Cell Line

Table 2

Relative organ weight of Sprague-Dawley rats following the 90-day oral pretreatment with vehicle (Tween 80) or MEMM in the subchronic toxicity study.

Organs	Male
	Control	Treatment
	Tween 80	MEMM (mg/kg)
	—	50	250	500
Spleen	0.21 ± 0.04	0.17 ± 0.01	0.20 ± 0.02	0.16 ± 0.01
Liver	2.76 ± 0.35	3.76 ± 0.07	2.93 ± 0.25	2.71 ± 0.12
Heart	0.35 ± 0.03	0.33 ± 0.01	0.34 ± 0.02	0.29 ± 0.02
Kidney	0.74 ± 0.06	0.64 ± 0.02	0.72 ± 0.03	0.61 ± 0.01
Lung	0.78 ± 0.07	0.71 ± 0.04	0.95 ± 0.13	0.90 ± 0.11
Colon	0.84 ± 0.13	0.77 ± 0.07	0.81 ± 0.07	0.70 ± 0.03

Values are expressed as means ± SEM. Groups (n = 6): control (treated with Tween 80); treatments (treated with 50 mg/kg MEMM, 250 mg/kg MEMM, and 1000 mg/kg MEMM).