Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods

Table 1

MS parameters of the five probe drugs and IS.

Probe drug	Precursor ion (m/z)	Product ion (m/z)	Fragmentor (V)	CE (V)
Omeprazole	346.2	136.1	80	35
Midazolam	326.1	291.1	160	25
Dextromethorphan	272.2	147.1	130	30
Phenacetin	180.1	110.1	100	17
Tolbutamide	271.1	91.1	100	17
Diazepam (IS)	285.1	193.0	130	30