Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods
Table 3
Pharmacokinetic parameters of the five probe drugs in different groups (n = 6).
Probe drug and group
Cmax (ng/mL)
T1/2 (h)
AUC(0–24) (h·ng/mL)
AUC(0–∞) (h·ng/mL)
MRT(0–24) (h)
MRT(0–∞) (h)
Omeprazole
Group A
4256.2 ± 1043.3
0.16 ± 0.03
1483.9 ± 366.0
1534.2 ± 383.7
0.86 ± 0.52
1.26 ± 0.77
Group B
4527.9 ± 534.1
0.15 ± 0.04
1459.9 ± 401.0
1485.3 ± 407.4
0.63 ± 0.53
0.74 ± 0.62
Group C
5010.3 ± 1175.5
0.17 ± 0.06
1601.7 ± 416.6
1665.8 ± 513.9
0.80 ± 0.61
1.62 ± 1.43
Midazolam
Group A
755.7 ± 172.1
0.25 ± 0.04
416.8 ± 82.3
424.9 ± 77.9
1.51 ± 1.14
1.90 ± 1.63
Group B
585.6 ± 38.3
0.24 ± 0.07
283.7 ± 65.2
292.0 ± 75.1
0.92 ± 0.63
1.17 ± 1.00
Group C
650.9 ± 217.9
0.25 ± 0.05
295.7 ± 62.7
299.5 ± 60.0
0.72 ± 0.22
0.91 ± 0.57
Dextromethorphan
Group A
342.7 ± 114.9
0.23 ± 0.20
540.7 ± 119.7
595.3 ± 122.2
3.12 ± 1.70
5.57 ± 3.52
Group B
428.8 ± 52.0
0.12 ± 0.12
760.6 ± 184.9
788.7 ± 211.0
3.66 ± 1.34
4.64 ± 2.04
Group C
464.2 ± 69.8
0.34 ± 0.28
734.3 ± 118.5
757.2 ± 105.4
3.18 ± 1.03
4.10 ± 2.11
Phenacetin
Group A
3458.3 ± 708.8
0.31 ± 0.07
1886.7 ± 602.0
1944.1 ± 578.1
0.89 ± 0.49
1.45 ± 1.16
Group B
4484.6 ± 366.7
0.26 ± 0.08
2025.4 ± 512.1
2067.7 ± 509.9
0.55 ± 0.32
0.74 ± 0.73
Group C
4745.9 ± 1238.9
0.24 ± 0.04
1922.8 ± 595.2
1943.5 ± 581.4
0.62 ± 0.52
1.01 ± 0.92
Tolbutamide
Group A
12402.5 ± 2375.8
0.06 ± 0.03
122412.8 ± 25958.5
141826.4 ± 36570.0
7.89 ± 0.72
11.73 ± 2.93
Group B
12397.5 ± 920.5
0.07 ± 0.01
124685.2 ± 19824.0
164218.1 ± 44237.0
8.75 ± 0.69
16.55 ± 5.52
Group C
13146.1 ± 3591.0
0.11 ± 0.10
112713.7 ± 19708.0
148136.8 ± 40794.2
8.31 ± 1.22
16.69 ± 13.26
, different from group A; , significantly different from group A.
