Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods
Table 4
The pharmacokinetic parameters of the analytes (n = 6).
Analytes and group
Cmax (ng/mL)
T1/2 (h)
Tmax (h)
Ke (h−1)
AUC(0–tn) (h·ng/mL)
AUC(0–∞) (h·ng/mL)
Metoprolol tartrate
Group A′
419 ± 181
1.28 ± 0.45
0.19 ± 0.06
0.62 ± 0.27
454 ± 113
529 ± 243
Group B′
307 ± 240
1.71 ± 1.11
0.38 ± 0.37
0.71 ± 0.65
350 ± 130
357 ± 136
Group C′
220 ± 81
1.73 ± 0.97
0.52 ± 0.49
0.54 ± 0.33
280 ± 69
285 ± 70
O-demethylmetoprolol
Group A′
157 ± 42
2.06 ± 0.61
0.73 ± 0.59
0.37 ± 0.12
456 ± 91
473 ± 126
Group B′
122 ± 28
2.56 ± 0.92
1.31 ± 0.37
0.30 ± 0.11
411 ± 49
414 ± 49
Group C′
160 ± 55
2.16 ± 0.84
1.21 ± 0.67
0.38 ± 0.18
536 ± 145
540 ± 146
α-Hydroxymetoprolol
Group A′
389 ± 159
2.08 ± 0.53
0.22 ± 0.04
0.36 ± 0.10
882 ± 144
893 ± 148
Group B′
238 ± 90
3.02 ± 1.32
1.31 ± 0.37
0.27 ± 0.12
736 ± 163
765 ± 151
Group C′
377 ± 102
2.26 ± 0.88
0.97 ± 0.69
0.35 ± 0.13
997 ± 162
1003 ± 162
, different from group A′; , significantly different from group A′.
