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Evidence-Based Complementary and Alternative Medicine
Volume 2019, Article ID 5376439, 13 pages
https://doi.org/10.1155/2019/5376439
Research Article

Fushiming Capsule Attenuates Diabetic Rat Retina Damage via Antioxidation and Anti-Inflammation

1Department of Chinese Material Medical and Natural Medicines, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
2Center of Clinical Aerospace Medicine, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
3Department of Pharmacy, Central Hospital of Ankang City, Ankang 725000, Shaanxi, China
4Xi’an Lejian Biological Technology Co., Ltd., Xi’an 710032, Shaanxi, China
5Academic Journals Publishing Center of Education Department, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China

Correspondence should be addressed to Siwang Wang; nc.ude.ummf@wisgnaw and Hongling He; moc.361@90.lhh

Received 26 January 2019; Accepted 21 March 2019; Published 18 July 2019

Guest Editor: José C. T. Carvalho

Copyright © 2019 Mengshan He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Diabetic retinopathy (DR) remains one of the leading causes of acquired blindness. Fushiming capsule (FSM), a compound traditional Chinese medicine, is clinically used for DR treatment in China. The present study was to investigate the effect of FSM on retinal alterations, inflammatory response, and oxidative stress triggered by diabetes. Main Methods. Diabetic rat model was induced by 6-week high-fat and high-sugar diet combined with 35 mg/kg streptozotocin (STZ). 30 days after successful establishment of diabetic rat model, full field electroretinography (ffERG) and optical coherence tomography (OCT) were performed to detect retinal pathological alterations. Then, FSM was administered to diabetic rats at different dosages for 42-day treatment and diabetic rats treated with Calcium dobesilate (CaD) capsule served as the positive group. Retinal function and structure were observed, and retinal vascular endothelial growth factor-α (VEGF-α), glial fibrillary acidic (GFAP), and vascular cell adhesion protein-1 (VCAM-1) expressions were measured both on mRNA and protein levels, and a series of blood metabolic indicators were also assessed. Key Findings. In DR rats, FSM (1.0g/kg and 0.5g/kg) treatment significantly restored retinal function (a higher amplitude of b-wave in dark-adaptation 3.0 and OPs2 wave) and prevented the decrease of retinal thickness including inner nuclear layer (INL), outer nuclear layer (ONL), and entire retina. Additionally, FSM dramatically decreased VEGF-α, GFAP, and VCAM-1 expressions in retinal tissues. Moreover, FSM notably improved serum antioxidative enzymes glutathione peroxidase, superoxide dismutase, and catalase activities, whereas it reduced serum advanced glycation end products, methane dicarboxylic aldehyde, nitric oxide, and total cholesterol and triglycerides levels. Significance. FSM could ameliorate diabetic rat retina damage possibly via inhibiting inflammation and improving antioxidation.