Study on the Antihypertensive Mechanism of Astragalus membranaceus and Salvia miltiorrhiza Based on Intestinal Flora-Host Metabolism

Table 1

16 potential biomarkers among the three groups.

Identification	Formula	Molecular Weight	RT; (min)	Change Trend; (HD:M / W:M)	Pathway
Taurocholic acid	C26H45NO7S	515.2900	14.3	↑ / ↑	Primary bile acid biosynthesis
5-Hydroxyindoleacetic acid	C10H9NO3	191.0580	8.36	↑ / ↑	Tryptophan metabolism
Indoleacetic acid	C10H9NO2	175.0631	9.46	↓ / ↓	Tryptophan metabolism
4-Pyridoxic acid	C8H9NO4	183.0530	5.75	↑ / ↑	Vitamin B6 metabolism
L-Kynurenine	C10H12N2O3	208.0748	3.75	↑ / ↑	Tryptophan metabolism
Adrenic acid	C22H36O2	332.2709	15.51	↓ / ↓	Biosynthesis of unsaturated fatty acids
Prostaglandin E2	C20H32O5	352.2247	10.63	↓ / ↓	Arachidonic acid metabolism
Leukotriene B4	C20H32O4	336.2296	12.19	↓ / ↓	Arachidonic acid metabolism
Gamma-Aminobutyric acid	C4H9NO2	103.0632	1.31	↑ / ↑	beta-Alanine metabolism
Testosterone	C19H28O2	288.2088	13.85	↓ / ↓	Steroid hormone biosynthesis
Sphinganine 1-phosphate	C18H40NO5P	381.2641	14.59	↑ / ↑	Sphingolipid metabolism
Arachidonic acid	C20H32O2	304.2399	13.62	↓ / ↓	Arachidonic acid metabolism
Glycine	C2H5NO2	75.0320	6.34	↑ / ↑	Glutathione metabolism
Cortisone	C21H28O5	360.1930	11.22	↓ / ↓	Steroid hormone biosynthesis
Beta-Estradiol	C18H24O2	272.1774	11.83	↑ / ↑	Steroid hormone biosynthesis
L-Glutathione (reduced)	C10H17N3O6S	307.0833	1.50	↑ / ↑	Glutathione metabolism

Note. Trends of HD group compared with M group. Trends of W group compared with M group. ↑: up-regulated. ↓: down-regulated.