Influence Factors on the Hepatotoxicity of Polygoni Multiflori Radix

Table 1

Patient details recorded from published case reports from year 2000.

Author	Country	Duration of intake, day	Clinical manifestations	Outcome	HSW type
Park et al. [8]	Australia	14	Malaise, nausea, emesis, pruritus, dark urine, and jaundice	Recovery	Shou-Wu-Pian
Yuan [9]	China	7	Fatigue and aggravated jaundice	Recovery	Ointment made by RHSW
Mazzanti et al. [10]	Italy	30	Jaundice, nausea, abdominal pain, yellow skin, and dark urine	Recovery	Shou-Wu-Pian
Wong et al. [11]	Netherlands	120	Jaundice, dark urine, and pale stools	Recovery	Shou-Wu-Pian
Cárdenas et al. [12]	Colombia	56	Maculopapular rash and mild eosinophilia	Recovery	Shen-Min
Fu and Yan [13]	China	18	Without clinical symptoms	Recovery	Chinese herbal medicine soup containing PHSW
Laird et al. [14]	America	Several months	Nausea and tea-colored urine	Recovery	NuHair
Cho et al. [15]	Korea	30	Fatigue and aggravated jaundice and fever and progressive pancytopenia	Recovery	Tea with RHSW
Furukawa et al. [16]	England	240	Fatigue	Recovery	Shou-Wu-Pian
Valente et al. [17]	Italy	14	Right upper abdominal pain, fatigue, jaundice, and nausea	Recovery	Shou-Wu-Pian
Li and Zhang [18]	China	60	Jaundice and abdominal pain	Recovery	Drink water with RHSW
		75	Jaundice	Recovery	Drink water with RHSW
Chen et al. [19]	China	1hour	Nausea and tea-colored urine	Recovery	RHSW
Hu et al. [20]	China	30	Fatigue and tea-colored urine	Recovery	Shouwu Yanshou pian
Cortez et al. [21]	Asia	60–90	Malaise, diarrhoea, myalgias, and arthralgias	Expire	Ban Tu Wan
Banarova et al. [22]	Slovenská republika	60	Nausea and jaundice	Recovery	Polygonum multiflorum pills
Zhen and Zeng [23]	China	14	Fatigue, nausea, and jaundice	Recovery	He Shouwu mixtures
Miao and Yun [24]	China	20	Jaundice and tea-colored urine	Recovery	PHSW powder
		180	Fatigue and tea-colored urine	Recovery	Drink water with RHSW
Li et al. [25]	China	30	Nausea, low-grade fever and tea-colored urine, and jaundice	Recovery	Wine made by PHSW
Lei and Li [26]	China	60	Fatigue and jaundice	Recovery	Steamed white rice with HSW
Zhang et al. [27]	China	45	Jaundice	Recovery	RHSW powder infused with water
Li et al. [28]	China	30	Fatigue, poor appetite, dark urine, and jaundice	Recovery	Qibao Meiran Wan