Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?

Figure 10

The regulation of Haizao Yuhu Decoction (HYD) for goiter. PTU inhibited thyroid hormone synthesis. The decreased serum levels of thyroid hormones negative feedback stimulated the secretion of TSH; then TSH stimulated hyperplasia and hypertrophy of thyroid follicular epithelial cells. Both HYD-H and HYD-Y could stimulate the expression of Bcl-2 and elevate the serum level of TRAb to inhibit the hyperplasia of follicular cells. HYD-Y also presented the function of altering the level of TSH in serum and the expression of Fas mRNA.