Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation

Figure 1

NMBA induces preneoplastic lesions of rat esophagus. (a) Pathological changes including normal epithelium, hyperplasia, mild dysplasia, moderate dysplasia, and severe dysplasia in rat esophageal mucosa (200×). (b) The occurrences of hyperplasia had statistical difference in control group and NMBA group at weeks 15, 25, and 35. The NMBA group also showed increased occurrence of hyperplasia at week 35 compared with weeks 15, 25. (c) The incidences of mild dysplasia in NMBA group at week 35 were statistically significant relative to weeks 15, 25. (d) and (e) The occurrences of moderate dysplasia and severe dysplasia in NMBA group at week 35 were higher than at weeks 15, 25 ( P<0.05, P<0.01, P<0.001).

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