Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation
Figure 2
JDTYS inhibits NMBA-induced preneoplastic lesions. (a) Representative figure of each group stained with H&E (200×). (b) At week 35, the occurrences of esophageal mucosal hyperplasia, in the ZSP, JDTYS 10 g/kg, and JDTYS 25 g/kg groups compared with the NMBA group. ( P<0.05, P<0.01, P<0.001). (c) At week 35, the mild dysplasia in the ZSP, JDTYS 10 g/kg, and JDTYS 25 g/kg groups was statistically different compared with the NMBA group. (d) The ZSP, JDTYS 10 g/kg and JDTYS 25 g/kg groups all significantly reduced the occurrences of moderate dysplasia ( P<0.05, P<0.01, P<0.001). (e) At week 35, the severe dysplasia in the ZSP, JDTYS 10 g/kg, and JDTYS 25 g/kg groups was statistically different compared with the NMBA group ( P<0.05, P<0.01, P<0.001). (f) JDTYS has no effect on the body weight of rats.