Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation

Figure 4

Effects of JDTYS on expression of inflammatory factors in the rat at week 35. (a) Immunohistochemistry analysis for NF-κB. The ZSP, JDTYS 10 g/kg, and JDTYS 25 g/kg groups showed reduced expression of NF-κB compared with the NMBA group (200×; P<0.05, P<0.01, P<0.001). (b) Rats esophageal epithelium in each group was stained with COX-2. The ZSP, JDTYS 10 g/kg, and JDTYS 25 g/kg groups significantly inhibited the expression of inflammation related protein COX-2 (200×; P<0.05, P<0.01, P<0.001).

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