Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation
Effects of JDTYS on expression of CD11B in the rat esophagus and COX-2, PTX3 expression in rat serum via immunoblotting and ELISA. (a) Rats esophageal epithelium samples were harvested and then stained with CD11B antibody. Expression of CD11B was calculated using positive staining cells. Each slide was counted, 5 separate areas. The JDTYS 10 g/kg and JDTYS 25 g/kg groups significantly reduced the expression of CD11B (400Ã—; P<0.05, P<0.01, P<0.001). (b) Collect rat serum to detect COX-2 expression. The ZSP, JDTYS 10 g/kg, and JDTYS 25 g/kg groups significantly reduced the expression of COX-2 in rat serum (P<0.05). (c) Rat serum was used to detect PTX3 expression. The JDTYS 25 g/kg group significantly increased the expression of PTX3 in rat serum (P<0.05).
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