Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3K/Akt/mTOR-Mediated Nrf2/HO-1 Pathway

Figure 5

EEBP activated PI3K/Akt/mTOR signaling pathway. (a), Expression of Akt, p-Akt, PI3K, and p-PI3K after treatment with EEBP in Ox-LDL induced HUVECs at 6 h, respectively. (b), Quantification of relative expression quantity of p-Akt and p-PI3K in Ox-LDL induced HUVECs at 6 h, respectively. (c), Expression of mTOR, p-mTOR, p70S6K, and p-p70S6K after treatment with EEBP in Ox-LDL induced HUVECs at 6 h. (d), Quantification of relative expression quantity of p-mTOR and p-p70S6K in Ox-LDL induced HUVECs at 6 h (P < 0.05, P < 0.01 vs Ox-LDL, n=3). Data are means ± S.E.M.

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