Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3K/Akt/mTOR-Mediated Nrf2/HO-1 Pathway

Figure 6

EEBP attenuated oxidative stress was PI3K/AKT/mTOR dependent. (a), Fluorescent micrographs of Nrf2 obtained in Ox-LDL induced HUVECs at 6 h after wortmannin treatment. (b), Expression of p-Akt, p-p70S6K, and HO-1 after wortmannin and EEBP treatment in Ox-LDL induced HUVECs at 6 h, respectively. (c), Quantification of relative expression quantity of p-Akt, p-p70S6K, and HO-1 in Ox-LDL induced HUVECs at 6 h, respectively (P < 0.05, P < 0.01 vs Ox-LDL, n=3). Data are means ± S.E.M.

(a)

(b)

(c)