Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 2 / Research Article
Identify the Key Active Ingredients and Pharmacological Mechanisms of Compound XiongShao Capsule in Treating Diabetic Peripheral Neuropathy by Network Pharmacology Approach Table 2 The information about the 25 key targets.
Gene UniProt Description Degree Source AKT1 P31749 RAC-alpha serine/threonine-protein kinase 83 validated OPRM1 P35372 Mu-type opioid receptor 76 predicted MAPK8 P45983 Mitogen-activated protein kinase 8 72 validated SLC6A4 P31645 Sodium-dependent serotonin transporter 67 predicted SLC6A2 P23975 Sodium-dependent noradrenaline transporter 60 validated SLC6A3 Q01959 Sodium-dependent dopamine transporter 56 predicted JUN P05412 Transcription factor AP-1 53 validated MAPK14 Q16539 Mitogen-activated protein kinase 14 51 predicted NOS3 P29474 Nitric oxide synthase 50 predicted TNF P01375 Tumor necrosis factor 40 validated ABCC8 Q09428 ATP-binding cassette sub-family C member 8 37 proteins FOS P01100 Proto-oncogene c-Fos 35 validated TUBB1 Q9H4B7 Tubulin beta-1 chain 34 predicted MAPK1 P28482 Mitogen-activated protein kinase 1 34 validated NFKB1 P19838 Nuclear factor NF-kappa-B p105 subunit 31 proteins BCL2 P10415 Apoptosis regulator Bcl-2 30 validated KCNJ11 Q14654 ATP-sensitive inward rectifier potassium channel 11 29 predicted PLAU P00749 Urokinase-type plasminogen activator 28 validated RELA Q04206 Transcription factor p65 23 validated TP53 P04637 Cellular tumor antigen p53 23 proteins BAX Q07812 Apoptosis regulator BAX 21 validated VEGFA P15692 Vascular endothelial growth factor A 21 validated STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta 19 validated FOXO1 Q12778 Forkhead box protein O1 19 proteins UBC P0CG48 Polyubiquitin-C 18 proteins
