Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of<i> Rhus coriaria</i> on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

<p>Effect of aqueous extract of<i> Rhus coriaria</i> fruits on myeloperoxidase (MPO) activity at a dose of 5 mg.mL<sup>−1</sup> of AERc (a) and at adose of 10 mg.mL<sup>−1</sup> of AERc (b) and hydroxyproline (HPX) in noninfected (c) and infected wounds (d) treated at 3, 6, 9, 15, and 21 postoperative days. In wounds infected with gram positive (<i>S. aureus</i>) and gram negative (<i>P. aeruginosa</i>), there was significant decrease (p=0.001) in the level of MPO activity and increase (p&lt;0.05) in the levels of HPX at days 15th, <span class="nowrap"><svg height="12.3641pt" id="M41" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -12.1577 20.989 12.3641" width="20.989pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M249 635C141 635 70 555 70 471C70 401 114 353 179 316C143 294 106 267 90 252C68 231 45 202 45 157C45 50 130 -12 237 -12C322 -12 435 52 435 169C435 256 372 304 303 343C349 374 375 398 383 407C401 429 411 458 411 487C411 569 344 635 249 635ZM238 603C285 603 337 567 337 482C337 422 310 385 276 358C205 393 145 426 145 500C145 552 179 603 238 603ZM248 20C183 20 125 70 125 163C125 218 158 268 206 300C284 261 355 217 355 143C355 66 308 20 248 20Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,12.527,-5.741)"><path d="M303 37L293 66C280 59 256 49 231 49S173 63 173 143V396H281C294 404 298 428 287 439H173V575L158 577L92 509V439H46L17 408L22 396H92V107C92 27 128 -12 192 -12C203 -12 218 -9 237 2L303 37Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,15.412,-5.741)"><path d="M522 0V30C462 35 455 41 455 106V280C455 397 397 451 314 451C262 451 206 414 171 379V710C131 698 69 682 20 675V647C87 642 90 637 90 574V106C90 41 80 35 20 30V0H236V30C176 35 171 43 171 106V339C198 371 237 391 276 391C341 391 374 350 374 269V106C374 43 367 35 308 30V0H522Z"></path></g></svg>,</span> and <svg height="11.2576pt" id="M42" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.2078 19.3631 11.2576" width="19.3631pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,12.527,-5.741)"><path d="M327 325C324 350 312 408 304 433C283 442 256 451 213 451C120 451 59 391 59 320C59 243 125 210 188 181C237 158 266 136 266 93C266 52 231 24 195 24C134 24 93 81 74 148L42 143C42 106 51 37 59 23C78 8 125 -12 177 -12C257 -12 345 35 345 127C345 198 292 234 216 264C171 283 131 305 131 348C131 387 156 416 195 416C243 416 277 378 297 317L327 325Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,15.903,-5.741)"><path d="M303 37L293 66C280 59 256 49 231 49S173 63 173 143V396H281C294 404 298 428 287 439H173V575L158 577L92 509V439H46L17 408L22 396H92V107C92 27 128 -12 192 -12C203 -12 218 -9 237 2L303 37Z"></path></g></svg> following treatment with AERc at doses of 5 mg.mL<sup>−1</sup>, 10 mg.mL<sup>−1</sup>, and compared with control treatments, respectively.</p>

Evidence-Based Complementary and Alternative Medicine

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Figure 3

Figure 3: Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of<i> Rhus coriaria</i> on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues 

Figure 3 | Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues 