Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

Table 6

Effect of aqueous extract of Rhus coriaria fruits on collagenase-2 (MMP-8), hydroxyproline (HPX), and collagen contents in infected and non-infected excision wounds.

Treatment	Wounds
	Non-infected			Infected
	MMP-8	Collagen	HPX	MMP-8	Collagen	HPX
Saline	48.9 ±8.5	5.4 ±0.47	115.4 ± 3.4	75.1±12.5	3.5 ±0.53	85.4 ± 2.9
Fibrase®	45.6 ±5.6	5.4 ±0.51	121± 6.4	71.3±6.5	3.6 ±0.35	89.1 ± 3.1
Dermazine®	41.3 ±4.7	5.1±0.43	118.7 ± 7.1	63.9±7.4	6.1 ±0.58	135 ± 5.4
AERc
5 mg.mL^−1	31.8 ±2.8	11.6±0.31	181.4 ± 5.7	58.9±4.9	10.2 ±0.72	169.8 ±2.1
10 mg.mL^−1	21.3 ±1.2	19.6±0.27	215.8 ± 9.1	44 ±6.1	15.7 ±0.35	269 ± 2.6

Values are mean ± SD of 10 rats in each group. < 0.05, < 0.01, and < 0.001 compared to respective control groups (Fibrase® and Dermazine®) and standard. Statistical analysis was done by one-way analysis of variance followed by Tukey-Kramer Multiple Comparisons Test.