Nerol Attenuates Ouabain-Induced Arrhythmias

Figure 1

Effects of nerol on the contractility of guinea pig left atrium and on the calcium influx. (a) Concentration-response curve for the negative inotropic effect of nerol (EC₅₀ = 1.94 ± 0.2 mM, n = 5). (b) Concentration-response curves of CaCl₂ in control situation and in the presence of nerol (n = 5). (c) Representative recording showing the L-type calcium currents (I_Ca,L) in control and 300 μM nerol. (d) Average effect of nerol on the I_Ca,L density (n = 7, p<0.05). Data are represented as mean ± SEM. Paired Student’s t-test.

(a)

(b)

(c)

(d)