Amelioration of CCl₄-Induced Hepatotoxicity in Rabbits by Lepidium sativum Seeds

Table 3

Liver profile of untreated, LSS administered, CCl₄ treated, and LSS protected rabbits. Effect of LSS on serum marker enzymes ALT, AST, GGT, ALP, T.BILI, TP, ALB, TG, and CHOL in rabbits treated with CCL₄ induced hepatotoxicity as indicated in the figure. All data were expressed as mean ± SEM. Values were statistically tested using the Student t-test and significant differences at p < 0.05 and p < 0.01 as indicated by ()& ()compared to normal control, by (#) & (##) compared to CCL₄ after 5 weeks, and by (+) & (++) compared to CCL₄ after 10 weeks, respectively.

Group	ALT (U/L)	AST (U/L)	G GT (U/L)	ALP (U/L)	T.BILI (mg/dl)	TP (g/dl)	ALB (g/dl)	CHOL (mg/dl)	TG (mg/dl)
Control	38.01 ± 4.68	27.25 ± 1.92	7.02 ± 1.24	22.02 ± 1.62	0.28 ± 0.03	6.50 ± 0.31	3.55 ± 0.17	16.32 ± 5.06	42.03 ± 4.69
LS (200mg/kg bw)	31.48 ± 6.78	29.41 ± 3.31	8.48 ± 1.20	57.02 ± 2.29	0.43 ± 0.03	6.40 ± 0.25	3.24 ± 0.13	32.17 ± 2.87	52.74 ± 2.79
LS (400mg/kg bw)	16.44 ± 1.46	20.76 ± 3.43	6.29 ± 2.29	53.08 ± 1.61	0.46 ± 0.03	5.86 ± 0.47	3.44 ± 0.10	31.61 ± 3.05	26.10 ± 3.04
CCl4 (5 wk.)	56.76 ± 5.46	62.30 ± 3.91	28.72 ± 2.76	114.83 ± 2.73	0.67 ± 0.04	4.14 ± 0.14	2.48 ± 0.25	89.21 ± 7.62	147.74 ± 7.44
% of Change	49	128	310	421	139	- 36	- 30	72	250
CCl4 (10 wk.)	67.00 ± 4.76	70.69 ± 6.45	39.78 ± 2.26	126.38 ± 3.71	0.60 ± 0.04	4.45 ± 0.1	2.61 ± 0.22	99.96 ± 6.16	163.79 ± 8.9
% of Change	76	159	468	474	114	- 31	- 26	5.12	2.9
CCl4 + LS (200mg/kg bw) 5 wk	30.62 ± 2.19##	24.90 ± 3.02##	19.62 ± 1.95 ##	59.60 ± 2.37##	0.33 ± 0.03##	6.49 ± 0.20##	3.39 ± 0.12##	51.35 ± 5.47##	89.78 ± 6.11##
% of Change	- 46	- 60	- 31	- 48	- 50	57	37	- 42	- 39
CCl4 + LS (400mg/kg bw) 5 wk	24.23 ± 2.91++	20.27 ± 3.09++	14.64 ± 1.73++	61.46 ± 4.16++	0.44 ± 0.03++	5.76 ± 0.62++	3.26 ± 0.20++	63.06 ± 5.24++	105.39 ± 5.62++
% of Change	- 57	- 67	- 49	- 46	- 34	39	31	- 29	- 28
CCl4 + LS (200mg/kg bw) 10 wk	38.04 ± 3.71##	23.90 ± 2.64##	15.81 ± 1.42##	52.59 ± 2.57##	0.38 ± 0.04##	6.36 ± 0.38##	3.38 ± 0.09##	52.36 ± 4.47##	98.70 ± 3.44##
% of Change	- 43	- 66	- 60	- 58	- 36	43	29	- 47	- 39
CCl4 + LS (400mg/kg bw)10 wk	40.18 ± 2.92++	25.16 ± 5.08++	22.92 ± 2.54++	79.54 ± 4.84++	0.48 ± 0.03 ++	6.35 ± 0.38++	3.34 ± 0.14++	65.57 ± 7.98++	105.13 ± 6.66++
% of Change	- 40	- 64	- 42	- 37	- 20	42	27	- 34	- 36