Amelioration of CCl₄-Induced Hepatotoxicity in Rabbits by Lepidium sativum Seeds

Table 4

Enzymatic activities of antioxidant enzymes and MDA of untreated, LSS administered, CCl₄ treated, and LSS protected rabbits. All data were expressed as mean ± SEM. Values were statistically tested using the Student t-test and significant differences at p < 0.05 and p < 0.01 as indicated by () & () compared to normal control, by (#) & (##) compared to CCL₄ after 5 weeks, and by (+) & (++) compared to CCL₄ after 10 weeks, respectively.

Group	CAT; (ng/g tissue)	SOD; (ng/g tissue)	GR; (ng/g tissue)	GST; (ng/g tissue)	GPx; (ng/g tissue)	MDA (nmol/ml)
Control	31.55 ± 1.99	28.20 ± 1.09	20.29 ± 0.99	15.37 ± 1.21	21.97 ± 1.70	6.47 ± 0.57
LS (200mg/kg bw)	31.27 ± 1.86	26.31 ± 1.55	19.08 ± 0.77	15.42 ± 0.67	21.29 ± 1.28	6.35 ± 0.45
LS (400mg/kg bw)	28.43 ± 2.04	26.76 ± 1.88	19.72 ± 1.28	15.55 ± 1.43	20.31 ± 0.74	6.35 ± 0.60
CCl4 (5 wk.)	14.75 ± 2.58	14.06 ± 1.39	13.58 ± 0.61	10.41 ± 1.08	14.09 ± 0.99	12.73 ± 1.06
% of Change	-53	- 50	- 33	- 32	- 35	96
CCl4 (10 wk.)	16.82 ± 1.57	17.67 ± 2.02	12.77 ± 1.36	9.40 ± 0.73	11.52 ± 1.82	14.27 ± 1.07
% of Change	- 46	- 37	- 37	- 39	- 47	120
CCl4 + LS (200mg/kg bw) 5 wk	28.46 ± 2.01##	27.20 ± 0.94##	18.92 ± 0.93##	14.72 ± 1.18##	20.09 ± 1.12##	6.67 ± 0.46##
% of Change	93	93	39	41	42	- 47
CCl4 + LS (400mg/kg bw) 5 wk	25.19 ± 1.77++	22.31 ± 1.40++	18.13 ± 0.94++	13.04 ± 1.31++	19.41 ± 1.92++	7.13 ± 0.72++
% of Change	70	58	33	25	37	- 44
CCl4 + LS (200mg/kg bw) 10 wk	28.72 ± 2.01##	27.96 ± 2.22##	19.49 ± 0.96##	14.92 ± 1.58##	20.06 ± 1.79##	5.69 ± 0.46##
% of Change	70	58	52	58	74	- 60
CCl4 + LS (400mg/kg bw) 10 wk	29.19 ± 1.70++	26.10 ± 1.43++	18.87 ± 1.73++	13.78 ± 0.86++	19.06 ± 1.41++	6.19 ± 0.52++
% of Change	73	47	47	46	65	- 56