Research Article
The Effects of Safflower Yellow on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Clinical Trial
Table 4
Clinical secondary outcomes.
| Secondary outcome factors | Intervention group (n = 63) | Control group (n = 64) | P value |
| Heart rate (beats/min) | | | | Before intervention | 95.56±17.31 | 94.69±12.64 | 0.748 | 72 h after intervention | 76.57±7.08 | 82.19±14.53 | 0.007 | Mean artery pressure (mmHg) | | | | Before intervention | 93.87±13.45 | 91.28±12.50 | 0.263 | 72 h after intervention | 88.83±7.46 | 88.02±8.55 | 0.57 | Arterial partial pressure of oxygen (PaO2, mmHg) | | | | Before intervention | 87.62±33.79 | 86.44±36.85 | 0.851 | 72 h after intervention | 105.08±29.00 | 93.58±25.06 | 0.018 | Arterial partial pressure of carbon dioxide (PaCO2, mmHg) | | | | Before intervention | 45.67±12.30 | 48.20±18.03 | 0.358 | 72 h after intervention | 43.20±7.62 | 45.93±11.10 | 0.109 | Respiratory frequency (breaths/min) | | | | Before intervention | 25.24±2.79 | 25.11±2.15 | 0.771 | 72 h after intervention | 19.60±3.09 | 22.66±2.65 | <0.001 | Leucocyte count (109/L) | | | | Before intervention | 9.07±4.05 | 8.07±3.19 | 0.126 | 72 h after intervention | 7.88±3.27 | 7.33±2.39 | 0.279 | Neutrophil ratio (NEUT%) | | | | Before intervention | 78.51±12.17 | 77.74±9.81 | 0.694 | 72 h after intervention | 73.26±10.69 | 71.09±9.35 | 0.226 | Platelet count (109/L) | | | | Before intervention | 142.25±44.03 | 133.97±42.68 | 0.284 | 72 h after intervention | 140.89±47.99 | 117.61±33.91 | 0.002 | Haemoglobin | | | | Before intervention | 125.65±16.27 | 127.78±21.19 | 0.527 | 72 h after intervention | 125.49±17.55 | 127.58±19.25 | 0.525 | Creatinine (mmol/L) | | | | Before intervention | 94.71±22.96 | 100.78±26.23 | 0.168 | 72 h after intervention | 91.88±26.62 | 91.19±16.88 | 0.86 | Alanine transaminase (ALT) | | | | Before intervention | 25.17±12.00 | 26.23±12.32 | 0.622 | 72 h after intervention | 27.17±11.77 | 28.63±14.59 | 0.539 | Prothrombin time PT (s) | | | | Before intervention | 12.54±1.17 | 12.50±1.20 | 0.861 | 72 h after intervention | 12.67±1.01 | 12.65±1.08 | 0.88 | Activated partial thromboplastin time APTT (s) | | | | Before intervention | 30.42±3.82 | 29.74±4.06 | 0.33 | 72 h after intervention | 30.15±3.16 | 30.20±2.77 | 0.932 | Rate of voluntary termination of treatment (%) | 4.76% (3/63) | 9.38% (6/64) | 0.492 |
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