The Effects of Safflower Yellow on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Clinical Trial

Table 4

Clinical secondary outcomes.

Secondary outcome factors	Intervention group (n = 63)	Control group (n = 64)	P value
Heart rate (beats/min)
Before intervention	95.56±17.31	94.69±12.64	0.748
72 h after intervention	76.57±7.08	82.19±14.53	0.007
Mean artery pressure (mmHg)
Before intervention	93.87±13.45	91.28±12.50	0.263
72 h after intervention	88.83±7.46	88.02±8.55	0.57
Arterial partial pressure of oxygen (PaO2, mmHg)
Before intervention	87.62±33.79	86.44±36.85	0.851
72 h after intervention	105.08±29.00	93.58±25.06	0.018
Arterial partial pressure of carbon dioxide (PaCO2, mmHg)
Before intervention	45.67±12.30	48.20±18.03	0.358
72 h after intervention	43.20±7.62	45.93±11.10	0.109
Respiratory frequency (breaths/min)
Before intervention	25.24±2.79	25.11±2.15	0.771
72 h after intervention	19.60±3.09	22.66±2.65	<0.001
Leucocyte count (10^9/L)
Before intervention	9.07±4.05	8.07±3.19	0.126
72 h after intervention	7.88±3.27	7.33±2.39	0.279
Neutrophil ratio (NEUT%)
Before intervention	78.51±12.17	77.74±9.81	0.694
72 h after intervention	73.26±10.69	71.09±9.35	0.226
Platelet count (10^9/L)
Before intervention	142.25±44.03	133.97±42.68	0.284
72 h after intervention	140.89±47.99	117.61±33.91	0.002
Haemoglobin
Before intervention	125.65±16.27	127.78±21.19	0.527
72 h after intervention	125.49±17.55	127.58±19.25	0.525
Creatinine (mmol/L)
Before intervention	94.71±22.96	100.78±26.23	0.168
72 h after intervention	91.88±26.62	91.19±16.88	0.86
Alanine transaminase (ALT)
Before intervention	25.17±12.00	26.23±12.32	0.622
72 h after intervention	27.17±11.77	28.63±14.59	0.539
Prothrombin time PT (s)
Before intervention	12.54±1.17	12.50±1.20	0.861
72 h after intervention	12.67±1.01	12.65±1.08	0.88
Activated partial thromboplastin time APTT (s)
Before intervention	30.42±3.82	29.74±4.06	0.33
72 h after intervention	30.15±3.16	30.20±2.77	0.932
Rate of voluntary termination of treatment (%)	4.76% (3/63)	9.38% (6/64)	0.492