Dracohodin Perochlorate Stimulates Fibroblast Proliferation via EGFR Activation and Downstream ERK/CREB and PI3K/Akt/mTOR Pathways In Vitro

Figure 5

Related signaling pathway inhibitors suppressed DP-induced protein phosphorylation. (a, c, e) with AG1478, U0126, or LY294002 respective pretreatment for 12 h, cells were treated with 3 μg/mL DP. Then, related protein expression was detected at 0, 5, 15, and 30 min after DP treatment. (b, d, f) Phosphorylation levels of related proteins were determined (data are presented as means ± SD, n = 5 for each bar. Single symbol, such as “,” indicates , and double symbols, such as “,” indicate vs. control group).

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