Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL/6 Mice

Table 5

Hematological values in male mice after 2 weeks of repeated oral administration of MO.

Parameters	Group (mg/kg/day)
	0	50	150	450
RBC (× 10^6/μg)	8.480 ±1.182	7.400 ± 2.224	8.680 ± 2.366	9.620 ± 0.554
HB (g/dL)	14.600 ±1.140	10.200 ± 3.347	12.600 ± 3.782	14.400 ± 0.894
HCT (%)	42.100 ± 11.520	36.480 ± 12.156	42.640 ± 12.182	47.680 ± 2.310
MCV (fl)	49.420 ± 1.099	48.820 ± 2.922	48.940 ± 1.122	49.640 ± 1.016
MCH (pg)	14.800 ± 0.447	14.200 ± 0.837	14.400 ± 0.894	14.800 ± 0.447
MCHC (g/dL)	29.880 ± 0.879	28.200 ± 2.021	28.860 ± 1.252	29.620 ± 0.610
PLT (× 10^3/μg)	729.400 ± 122.100	685.200 ± 249.905	661.000 ± 83.382	715.800 ± 65.370
WBC (× 10^3/μg)	2.240 ± 1.314	2.720 ± 1.224	2.320 ± 1.274	3.160 ± 1.383
NEU (%)	15.320 ± 9.066	10.200 ± 1.495	17.360 ± 8.914	21.180 ± 15.790
LYM (%)	79.140 ± 11.305	84.960 ± 3.087	76.440 ± 9.095	74.360 ± 17.568
MON (%)	3.300 ± 0.846	3.280 ± 1.152	3.440 ± 1.410	2.960 ± 1.601
EOS (%)	1.640 ± 2.263	1.100 ± 1.177	1.860 ±1.633	1.040 ± 1.488
BAS (%)	0.620 ± 0.567	0.480 ± 0.634	0.900 ± 0.552	0.460 ± 0.650

RBC, red blood cells; HB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin;
MCHC, mean corpuscular hemoglobin concentration; PLT, platelet; WBC, white blood cell; NEU, neutrophil; LYM, lymphocyte;
MON, monocyte; EOS, eosinophil; BAS, basophil.
Values are expressed as means ± SD of five mice at sacrifice.