Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice
Table 2
Body weight of Plasmodium berghei infected mice after administration of the leaf latex and TLC isolates of Aloe megalacantha.
Test substance
Dose (mg/kg/day)
Wt D0 (g)
Wt D4 (g)
Mean difference
NC
10 ml/kg
21.9 ± 0.63
20.9 ± 0.64
-1.0 (4.6)
Latex
100
23.2 ± 0.48
23.1 ± 0.44
-0.1 (0.4)
200
21.4 ± 1.22
21.7 ± 1.01
0.3 (1.4)
400
20.1 ± 0.23
21.2 ± 0.59
1.1 (5.5)
AM1
100
20.6 ± 0.38
20.8 ± 0.42
0.2 (1.0)
200
20.7 ± 0.38
21.6 ± 0.32
0.9 (4.4)
400
21.1 ± 0.35
22.4 ± 0.56
1.3 (6.2)
AM2
100
22.3 ± 0.91
22.7 ± 1.03
0.2 (0.9)
200
21.7 ± 0.67
22.8 ± 0.78
1.1 (5.1)
400
21.2 ± 0.45
22.7 ± 0.28
1.5 (7.1)
AM3
100
20.6 ± 0.48
21.8 ± 0.47
1.2 (5.8)
200
21.9 ± 0.45
23.5 ± 0.88
1.6 (7.3)
400
21.3 ± 0.46
23.3 ± 0.57
2.0 (9.4)
CQ
25
21.9 ± 0.38
23.2 ± 0.27
1.3 (5.9)
Values are presented as M ± SEM; n refers to number of mice, n = 5; Wt D0: weight before treatment on day zero; Wt D4: weight after treatment on fifth day (day 4); values in parenthesis indicate percent of change.
