Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice

Table 3

Mean difference of rectal temperature of P. berghei infected mice after treatment with leaf latex and TLC isolates obtained from A. megalacantha.

Test substance	Dose (mg/kg/day)	T^0 D0 (°C)	T^0 D4 (°C)	Mean difference
NC	10 ml/kg	37.8 ± 0.31	34.6 ±0.33	-3.2 (8.5)
Latex	100	38.02 ± 0.22	35.66 ± 0.13	-2.36 (6.6)
	200	37.45 ± 0.26	35.82 ± 0.31	-1.63 (4.6)
	400	37.5 ± 0.28	36.16 ± 0.21	-1.34 (3.7)
AM1	100	37.7 ± 0.19	35.9 ± 0.29	-1.7 (4.5)
	200	37.6 ± 0.37	36.6 ± 0.22	-1.0 (2.7)
	400	37.7 ± 0.33	36.8 ± 0.27	-0.9 (2.4)
AM2	100	37.6 ± 0.30	36.1 ± 0.50	-1.5 (4.0)
	200	37.4 ± 0.28	36.6 ± 0.52	-0.8 (2.1)
	400	37.4 ± 0.26	36.7 ± 0.31	-0.7 (1.9)
AM3	100	37.6 ± 0.24	36.5 ± 0.17	-1.1 (2.9)
	200	37.6 ± 0.23	36.7 ± 0.17	-0.9 (2.4)
	400	37.8 ± 0.33	36.9 ± 0.26	-0.9 (2.4)
CQ	25	37.4 ± 0.32	37.7 ± 0.26	0.3 (0.8)

Values are presented as M ± SEM; n =5; mean value is significant (P<0.001) when compared with negative control group; T⁰ D₀: temperature before treatment on day zero; T⁰ D₄: temperature after treatment on fifth day (day 4); values in parenthesis indicate % of change.