Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 1

Review Article

An Overview of the Randomized Placebo-Controlled Trials of Chinese Herbal Medicine Formula Granules

Table 1

Characteristics of the included studies.

Study IDDiseasesSample
T/C
Age
(years)
Gender
M/F
TreatmentDurationMain outcomes

Cheng Y 2016 [10]fever41/40T:38.03 ± 14.65
C:37.21 ± 15.43
T:22/19
C:20/20
Clearing heat and removing toxicity formula3 dFever clearance time, AE

Xie JH 2017 [11]fever48/48T:36.7 ± 6.7
C:39.4 ± 2.1
T:25/23
C:20/28
Clearing heat and removing toxicity formula3 dsymptoms improving, AE

Li Y 2012 [12]AIDS36/3618-7046/26Improving immunity formula180 dCD4

Cheng Y 2017 [13]non-alcoholic
fatty liver
48/48T:45.07 ± 11.23
C:41.65 ± 9.38
T:23/17
C:25/15
Invigorating spleen, regulating Qi and resolving dampness formula24 wFree fatty acids, ALT, AE

Fu CH 2014 [14]migraine150/78T:37.11 ± 11.96
C:34.97 ± 10.40
T:33/96
C:12/52
Modified Rhizoma Chuanxiong releasing pain decoction or Wuzhuyu decoction12 wNo. and degree of headache

Xu YL 2011 [15]migraine24/2418~65T:5/19
C:11/13
Regulating liver, dispelling wind and removing blood stasis formula12 wNo. and degree of headache, AE

Zhang Y 2013 [16]migraine86/42T:23 ~ 56
C:24 ~ 54
T:23/63
C:11/31
Modified Chuanxiong Dingtong decoction12 wNo. of headache, PSQI scale, EO

Geng YY 2015 [17]asthma40/20T:3.62 ± 0.88
C:3.37 ± 0.90
T:30/10
C:17/3
Nourishing Qi to invigorate spleen and invigorating the kidney formula12 wNo. of asthma attacks, AE

He JS 2012 [18]HBV
carrier
200/100T:33.6 ± 7.1
C:34.4 ± 8.2
T:137/63
C:60/40
Notifying kidney and spleen formula52 wHBV DNA, HBeAg, HBsAg, AE

Li HZ 2012 [19]HBV
carrier
200/100T:34.33 ± 6.22
C:34.39 ± 8.18
T:118/82
C:59/41
Notifying and clearing kidney formula52 wHBV DNA, HBeAg

Ni W 2015 [20]HBV
carrier
40/2036. 24 ± 8. 22T:19/21
C:12/8
Notifying and clearing kidney formula48 wHBV DNA, HBeAg, AE

Peng DT 2016 [21]HBV
carrier
50/25T:34.67 ± 5.12
C:32.20 ± 3.95
T:24/26
C:14/11
Notifying kidney and detoxifying formula48 wHBV DNA, HBeAg, HBsAg, AE

Xing YF 2012 [22]HBV
carrier
200/200T:34.33 ± 6.22
C:34.39 ± 8.18
T:113/78
C:112/75
Notifying and clearing kidney formula52 wHBV DNA, AE

Zheng YJ 2012 [23]HBV
carrier
60/60T:35.0 ± 5.0
C:34.0 ± 6.0
T:42/18
C:45/15
Notifying kidney and spleen formula48 wHBV DNA, HBeAg, AE

Zhang ZE 2013 [24]HBV
recrudescence
23/23T:37.7 ± 12.5
C:38.1 ± 12.0
T:12/11
C:13/10
Notifying kidney and spleen formula48 wHA, PCIII, AE

Xu F 2013-1 [25]depressed50/50T:30.43 ± 3.43
C:30.07 ± 3.34
-Benefiting brain and relieving depression formula6 wEdinburgh Postnatal Depression Scale, AE

Xu F 2013 [26]depressed47/46--Ease powder6 wcognitive function, AE

Zhao L 2014 [16]HCV102/1021b:54.7 ± 12.47
other:49.5 ± 16.7
T:81/48
C:24/20
Qizhu (astragalus and atractylodes) granules48 wHCV RNA

Zhao L2014-1 [27]HCV96/96T:53.47 ± 12.80
C:53.27 ± 13.24
T:39/57
C:34/52
Qizhu (astragalus and atractylodes) granules48 wHCV RNA, AE

Chen SQ 2017 [28]COPD60/60T:65.06 ± 5.05
C:66.08 ± 6.04
T:29/31
C:32/28
Modified Erchen decoction combined with antibiotics, bronchiectasis and oxygen uptake14 dPulmonary function, IgA, AE

Xie WY 2017 [29]COPD
stable period
COPD
acute period
60/60
60/60
T:65.05 ± 5.07
C:68.07 ± 6.15
T:68.12 ± 5.07C:68.11 ± 6.06
T:33/27
C:31/29
T:32/28
C:30/30
Modified Erchen decoction combined with antibiotics, bronchiectasis and oxygen uptake14 dPulmonary function

Shang LZ 2017 [30]COPD100/100T:69.48 ± 9. 05C:70.39 ± 8. 84T: 57/43
C: 55/45
Modified Erchen decoction combined with antibiotics, bronchiectasis and oxygen uptake14 dPulmonary function

Hu WH 2015 [31]diabetic peripheral neuropathy50/50T:54.5(43-68)
C:53.2(46-69)
T:24/26
C:22/28
Eliminating arthralgia and promoting blood circulation granules combined with methycobal and antidiabetics8 wPain, neurological function

Li M &
Yang MH [3240]
Parkinson’s
disease
60/60T:66.6 ± 1.2
C:67.3 ± 1.2
T:31/27
C:42/20
Notifying the kidney and promoting blood circulation formula combined with madopar36 wUnified Parkinson’s disease rating scale, AE

Liu J 2012 [41]depression30/30T:40.13 ± 9.72
C:41.25 ± 9.59
T:14/18
C:13/20
Relieving depression granules combined with paroxetine8 wHAMD Scale, AE

Pang LJ 2013 [42]angina pectoris35/35T:57.2 ± 9.2
C:60.13 ± 3.8
T:15/15
C:15/15
Promoting blood circulation and resolving turbidity formula combined with aspirin8 wPain, attacks, ECG, nitro-glycerine

Shuang XP 2014 [43]myasthenia
gravis
20/18T:22-60
C:20-59
T:8/12
C:7/11
Notifying Qi and dehumidification formula combined with prednisone and pyridine bromide10 wMyasthenia gravis scale

Song JK 2016 [44]herpes simplex keratitis (liver-wind and deficiency of liver-Yin)35/40
38/40
T:36.5 ± 7.3
C:38.2 ± 8.6
T:46.5 ± 8.2
C:44.2 ± 7.6
T:17 /16
C:16 /15
T:15/17
C:16 /18
Clearing or softening liver formula combined with ganciclovir7 dSymptoms, laboratory test, AE

Xie WN 2016 [45]HBV40/40T:27.43 ± 5.75
C:28.72 ± 6.42
T:30/10
C:31/9
Notifying kidney and spleen formula combined with lamivudine48 wHBV DNA, HBeAg, AE

Ye YA 2012 [46]HBV295/295--Regulating liver and blood and notifying spleen/Regulating liver, detoxification and dehumidification combined with adefovir dipivoxil48 wHBeAg

Zhan BL 2013 [47]HBV30/30T:34.26 ± 9.41
C:36.19 ± 10.29
T:21/9
C:19/11
Regulating liver and blood and notifying spleen/Regulating liver, detoxification and dehumidification combined with adefovir dipivoxil48 wHBV DNA, HBeAg, AE

Zhang PJ 2013 [48]liver cirrhotic
ascites
56/56T:42.7 ± 6.42
C:44.72 ± 5.48
T:32/24
C:30/26
Alleviating water retention formula28 dLiver function

AE: adverse event; -: undescribed.

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