Review Article
An Overview of the Randomized Placebo-Controlled Trials of Chinese Herbal Medicine Formula Granules
Table 3
Comparison of the cure rate between CHM formula granules and placebo based on conventional therapy.
| | Study ID | Treatment | Placebo | P value | | n/N | % | n/N | % |
| | Chronic Hepatitis B: HBV DNA negative after 48-week treatment | | Zhan BL 2013 | 24/30 | 80.00 | 16/30 | 53.33 | 0.07 |
| | Chronic Hepatitis B: HBeAg negative after 48-week treatment | | Ye YA 2012 | 83/280 | 29.64 | 50/280 | 17.86 | 0.001 | | Zhan BL 2013 | 14/30 | 46.67 | 6/30 | 20.00 | 0.04 | | Meta-analysis RR and 95% CI: 1.73 ; I2 = 0% |
| | Chronic Hepatitis B with YMDD: HBV DNA negative after 48-week treatment | | Xie WN 2016 | 7/36 | 19.44 | 1/33 | 3.03 | 0.07 |
| | Chronic Hepatitis B with YMDD: HBeAg negative after 48-week treatment | | Xie WN 2016 | 9/36 | 25.00 | 0/31 | 0.00 | 0.05 |
| | Herpes simplex keratitis: Symptoms disappeared and normal laboratory test | | Song JK 2016 | 24/33 | 72.73 | 14/31 | 45.16 | 0.03 | | Song JK 2016a | 23/34 | 67.65 | 13/32 | 40.63 | 0.04 |
| | Depression: The score of HAMD-17 <7 | | Liu J 2012 | 12/32 | 37.50 | 8/33 | 24.24 | 0.25 |
| | Myasthenia gravis: Reduction of the score of myasthenia gravis scale≥95 | | Shuang XP 2014 | 0/20 | 0.00 | 0/18 | 0.00 | - |
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