Development of a HPLC-MS/MS Method to Determine the 13 Elements of Semen Cuscutae and Application to a Pharmacokinetic Study in Rats

Table 6

Pharmacokinetic parameters of 7 analytes after oral administration of Semen Cuscutae extract (n = 6).

Compounds	Tmax (h)	Cmax (ng/mL)	t1/2 (h)	AUC(0-tn) (h·ng/mL)	AUC(0-∞) (h·ng/mL)
Hyperoside	0.17 ± 0.07	29.81 ± 12.78	0.36 ± 0.23	684.47 ± 406.92	753.93 ± 423.71
Caffeic acid	0.28 ± 0.04	33.66 ± 8.43	11.60 ± 0.92	613.06 ± 290.85	651.94 ± 291.89
Rutin	10.00 ± 0.03	157.68 ± 84.08	7.70 ± 0.90	4463.92 ± 2274.52	4793.86 ± 2243.02
Chlorogenic acid	0.22 ± 0.06	35.51 ± 7.30	1.02 ± 0.67	994.54 ± 654.39	1000.96 ± 645.80
Isoquercitrin	0.21 ± 0.07	52.61 ± 7.55	0.49 ± 0.05	838.79 ± 518.04	949.49 ± 594.15
Isorhamnetin-3-O-glucoside	0.30 ± 0.01	19.51 ± 9.80	1.23 ± 0.26	171.70 ± 49.21	256.76 ± 74.37
Astragalin	0.24 ± 0.09	58.18 ± 28.53	0.45 ± 0.26	370.23 ± 258.63	440.81 ± 291.89