Evidence-Based Complementary and Alternative Medicine

Review Article

Adjuvant Treatment of Crohn’s Disease with Traditional Chinese Medicine: A Meta-Analysis

Table 1

Characteristics and methodological quality of included studies.


Study ID	Sample size (E/C)	Sex		Age (E/C)	Therapy		Duration (weeks)	Outcome
Study ID	Sample size (E/C)	M(E/C)	F(E/C)	Age (E/C)	Experimental	Control	Duration (weeks)	Outcome

Zhang 2018	44/44	24/26	20/18	38.6±7.2 (23~58)/36.9±8.3(25~54)	TCM+Prednisone	Prednisone	8	Efficacy, ESR, CRP,CDAI, Side effects
Wang 2018	62/62	36/34	26/28	37.10±5.68(21~65)/36.61±5.29(19~65)	TCM+Thalidomide	Thalidomide	12	Efficacy, ESR, CRP,CDAI
Cui 2017	20/20	11/10	9/10	42.25±15.37/35.25±14.46	TCM+Mesalamine	Mesalamine	12	Efficacy, ESR, CRP,CDAI, Side effects
Li 2017	15/15	10/9	5/16	28.4 ±3.8(22~46)/27.8±3.4 (20~42)	TCM+ Sulfasalazine	Sulfasalazine	24	Efficacy, Side effects, Recurrence
Deng 2016	30/30	- - - -	- - - -	_	TCM+ Mesalamine	Mesalamine	12	Efficacy
Zhen 2015	40/40	23/21	17/19	37.8 ±6.5(21~63)/36.8±5.7(19~65)	TCM+ Methotrexate	Methotrexate	8	Efficacy, ESR, CRP,CDAI, Side effects
Wang 2014	20/20	12/11	8/9	35.70±13.07(18~60)/37.85±12.42(18~65)	TCM+ Mesalamine	Mesalamine	24	Efficacy, ESR, CRP, Recurrence
Fan 2014	15/15	- - - -	- - - -	(18~65)	TCM+Prednisone	Prednisone	24	Efficacy, ESR, CRP, CDAI, Mucosal healing
Li 2013	10/10	7/6	3/4	35 ±13(18~65)/38±10(18~65)	TCM+Prednisone	Prednisone	24	Mucosal healing
Xun 2012	24/24	- - - -	- - - -	28.12±2.57(18~45)	TCM+Sulfasalazine	Sulfasalazine	24	Efficacy, Recurrence
Ma 2012	16/16	- - - -	- - - -	28.12±2.57(18~45)	TCM+Prednisone	Prednisone	10	Efficacy
Zou 2012	28/30	15/16	13/14	35.89±11.49(15~70)/34.29±17.91(15~70)	TCM+ Sulfasalazine	Sulfasalazine	4	ESR, CDAI

Notes: CDAI: Crohn’s disease activity index; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; E: experimental group; C: control group; TCM: Traditional Chinese Medicine; WM: Western Medicine.