Research Article
Hypoglycemic and Toxic Effect of Morus mesozygia Leaf Extract on the Liver and Kidneys of Alloxan-Induced Hyperglycemic Wistar Rats
Figure 3
Microphotograph of the liver (H&E, ×200) of alloxan-induced hyperglycemic adult wistar rats exposed to 200 mg, 400 mg, and 800 mg of Morus mesozygia for 14 days. In the diabetic control group, the arrow head points at an area of the liver that exhibited focal hepatocellular necrosis with mononuclear cell infiltration (granuloma). These rats died before the 14th day because of the effects of hyperglycemia. There were no observed significant lesions in all the test groups. Note: central vein (CV), hepatocyte plates (H), and sinusoidal spaces (S) are shown in the micrographs stained with hematoxylin and eosin (H&E). (a) Diabetic control group. (b) 200 mg group. (c) 400 mg group. (d) 800 mg group. (e) Glibenclamide control.
| (a) |
| (b) |
| (c) |
| (d) |
| (e) |