Hypoglycemic and Toxic Effect of Morus mesozygia Leaf Extract on the Liver and Kidneys of Alloxan-Induced Hyperglycemic Wistar Rats
Table 2
Results showing reduction in glucose levels from the 0 to 4th hour during the experiment.
Extract/control dose
Mean glucose level at 0 hour ± SD (mg/dl)
value (ANOVA)
Mean glucose level at 4th hour ± SD (mg/dl)
value (ANOVA)
Mean glucose reduction from 0 to 4 hours (mg/dl)
Mean glucose reduction from 0 to 4 hours (%)
Days 1–4
200 mg
393.8 ± 27.23
0.991
273 ± 16.23
0.012
23
6.21
400 mg
312 ± 16.22
0.053
297.2 ± 31.23
0.772
61.75
14.72
800 mg
381.6 ± 19.34
0.495
386.2 ± 23.45
0.584
46.88
10.05
Gliben
408.2 ± 42.11
0.006
261.6 ± 11.43
0.84
159.75
35.48
Dmcont
455 ± 34.22
0.009
472 ± 33.23
0.0084
−12.2
−6.42
Days 5–8
200 mg
371.5 ± 14.23
0.552
231 ± 18.35
0.150
58.25
15.38
400 mg
266 ± 23.12
0.300
242.2 ± 11.56
0.08
50.65
28.03
800 mg
386.33 ± 10.12
0.029
416 ± 22.23
0.0016
109.67
37.23
Gliben
334.67 ± 25.3
0.439
196.67 ± 27.12
0.990
68.17
24.14
Dmcont
76 ± 6.87
0.753
76 ± 11.5
0.962
2.55
3.19
Days 9–14
200 mg
234 ± 29.23
0.996
236 ± 24.23
0.936
10.53
3.32
400 mg
73 ± 13.02
0.558
43.4 ± 13.65
0.703
20.11
31.16
800 mg
163 ± 25.23
0.629
29.3 ± 15.31
0.605
116.44
65.67
Gliben
285 ± 23.34
0.0042
199.3 ± 35.53
0.298
62.17
38.85
Dmcont
82.8 ± 14.92
0.114
78.2 ± 12.12
0.015
0.33
0.367
Note that the rats in the Dmcont group died of hyperglycemia. Gliben = diabetic-induced rats that received glibenclamide; Dmcont = diabetic-induced rats that received normal saline; SD = standard deviation. Statistically significantly different ().
