Research Article
The Role of Adenosine A2b Receptor in Mediating the Cardioprotection of Electroacupuncture Pretreatment via Influencing Ca2+ Key Regulators
Table 2
The variation of proteins related to the calcium regulation.
| | Receptors/proteins | Roles played by the proteins | EA vs. M | EAG vs. EA |
| | A2b | Related to calcium regulation | ↑ | ↓ | | Ryanodine 2 | Releasing Ca2+ from SR into the cytoplasm and related to the myocardial contraction | ↓ | ↑ | | SERCA 2a | Calcium pump to uptake Ca2+ into SR and related to myocardial diastolic | ↑ | — | | NCX1 | Removing Ca2+ from the cytoplasm by exchanging Na+ into the cells | — | — | | P-PLB(S16)/PLB | Regulating the function of SERCA2a, related to uptake intracellular Ca2+ into SR | ↑ | ↓ | | Troponin C/I | The binding degree of cardiac myocytes to calcium | ↓ | ↑ |
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↑, upregulated; ↓, downregulated; —, unchanged.
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